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The concomitant usage of DEMEROL Tablets or Oral Remedy and CYP3A4 or CYP2B6 inducers can lessen the plasma concentration of meperidine [see Medical Pharmacology (twelve.three)], resulting in lessened efficacy or onset of the withdrawal syndrome in people which have produced physical dependence to meperidine [see Warnings and Safeguards (5.Get
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